Avoid Eating Fatty And Salty Foods
Obesity is one of the great causes of vein disease. Eating non-fat food and exercising regularly will help one to maintain a healthy weight range. Salty foods result in greater water retention, which puts excessive pressure on your varicose veins.
Consuming salty foods like bread, pizza, cold cuts, etc., can cause water retention, which consequently hinders blood flow. Cutting back on sodium can help you solve this problem. You can easily avoid excessive salt by checking the nutritional facts of any packaged food.
Endothelial Dysfunction And Changes In Vascular Structure
There is increasing evidence supporting the significance of vascular endothelial dysfunction in the pathogenesis of hypertension. Obesity represents a state of inflammation that can cause endothelial dysfunction. Insulin resistance, low levels of adiponectin, high plasma leptin, increased levels of plasma glucose and FFAs are considered as indices of an inflammation compatible profile. A series of insulin signaling pathways are instructed to function in favor of inflammation and uncontrolled endothelial growth causing endothelial dysfunction and finally hypertension.
A variety of biologically active derivatives generate from adipose cells, including reactive oxygen species, proinflammatory and inflammatory molecules , angiogenetic factors , hemostasis modulating compounds and acute phase reaction proteins . Activation of nuclear factor light-chain enhancer of activated B cells and IB kinase because of fat accumulation is of great significance for the establishment of a proinflammatory and prothrombotic state, indicating the presence of altered vascular function that predisposes to the development of hypertension.
What Is Venous Insufficiency
Your arteries carry blood from your heart to the rest of your body. Your veins carry blood back to the heart, and valves in the veins stop the blood from flowing backward.
When your veins have trouble sending blood from your limbs back to the heart, its known as venous insufficiency. In this condition, blood doesnt flow back properly to the heart, causing blood to pool in the veins in your legs.
Several factors can cause venous insufficiency, though its most commonly caused by blood clots and varicose veins.
Even if you have a family history of venous insufficiency, there are simple steps you can take to lower your chances of developing the condition.
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Effect Of Treatments On Hepatic Enzymes And Lipid Peroxidation In Hfd
The current data showed a significant increase in the activity of enzymes AST and ALT in the obese compared with normal rats . Liver is bombarded by the free fatty acids that pour out of the adipose tissue into the portal blood. This can directly cause inflammation within the liver cells, which then release further pro-inflammatory cytokines, leading to more hepatocyte injury and affecting the integrity of liver cells .
Administration of L-carnitine produces a significant lowering effect in the activity of AST and ALT in obese rats, a result in agreement with Yapar et al. . Improvement of hepatocyte integrity does not seem to be limited to its obligatory role in the transmembrane import of fatty acids for mitochondrial -oxidation, but L-carnitine prevents lipotrope methyl group wastage and increased production of polyamines with known immunomodulatory properties. Additionally L-carnitine can directly modify cytokine responses and reduce TNF-production. Moreover, lipid peroxidation is significantly blunted by oral administration of L-carnitine .
The present results demonstrate that the mixture of HMF showed a significant decrease in the activity of both AST and ALT agreeing with the resulted obtained by Celik and Isik .
HFD generates oxidative stress in obese rats as shown by a marked increase in the levels of MDA and a distinct diminution in hepatic GSH, as well as activities of the antioxidant enzyme catalase. All showed reduced activity in hyperlipidemic rats .
The Basics Of Venous Insufficiency
Vein diseases such as varicose veins, spider veins, and venous insufficiency or venous reflux are so common that you might think of them as harmless, but theyre not always purely cosmetic. They can be painful and uncomfortable, and should be treated. You can take steps to manage venous insufficiency yourself, but a visit to a vein clinic can be necessary if you dont get the condition under control.
Causes and Effects of Venous Reflux
Normally, your vein return blood to your heart so it can be circulated again in the body. Venous reflux occurs when your veins are unable to return blood as efficiently. The following are common causes of venous reflux.
- Varicose veins, which dont function as well as healthy veins and have blood pooled in them.
- Blood clots, which interfere with regular blood flow.
- Damage to valves in the vein, which allow blood to flow backwards instead of progressing forward to the heart.
- Weak leg muscles which are unable to squeeze hard enough to get blood back to the heart.
If you have venous reflux, you can experience the following symptoms.
- Swelling in your legs.
- Aching, cramping, and throbbing in your legs.
Home Remedies for Venous Reflux
Obesity is a risk factor for venous insufficiency. You can reduce your risk of developing it and slow progression by losing extra pounds. A safe way to lose weight is to eat smaller portions and choose healthy foods, such as vegetables, lean proteins, fruits, and beans.
Therapies from a Vein Clinic
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The Real Weight Of Obesity
As a general rule, obesity is usually associated with a decrease in physical activity. This more sedentary life style results in much less activation of the lower extremity muscle pumps which help return blood to the heart.
Obesity is also correlated with heart disease- ASCAD or arteriosclerotic coronary artery disease. People with this problem have a host of factors that come into play, resulting in decreased blood flow back to the heart, increased pressure in the lower extremity veins, and increased incidence and severity of chronic venous insufficiency .
Prevention Of Chronic Venous Insufficiency
Primary prevention involves adequate anticoagulation after DVT and use of compression stockings for up to 2 years after DVT or lower extremity venous trauma. However, a recent study using sham-compression stockings failed to show any decrease in postphlebitic syndrome. Lifestyle changes can decrease risk by decreasing lower extremity venous pressure.
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When Exercise Isnt An Option
At The Vein Care Center of Florida & South Baldwin, we recognize that regular exercise may not be feasible for some patients. If exercise isnt an option, there are still a few things you can do to improve your circulation and overall vein health:
- Wear compression stockings to help blood flow in the proper direction
- Calf raises or rocking your heels back and forth can help activate the calf pump muscle to improve circulation
- Elevate your legs to reduce swelling and keep blood from pooling
- Rotate your ankles to help blood flow back to the heart
While exercise cant cure or prevent venous disease, it can help to alleviate uncomfortable symptoms and improve the health of your veins. Its important not to over-exert yourself, however, as this can cause strain and pressure that can cause swelling or discomfort. If youre interested in learning more about how you can treat the symptoms of venous insufficiency, the vein care specialist Dr. James Jimenez at The Vein Center of Florida & South Baldwin offers a variety of effective treatments for Florida patients in Pensacola or Destin, or Alabama patients in Foley. Contact or call The Vein Center of Florida & South Baldwin at 1-800-910-VEIN to set up a consultation or receive a free vein screening today!
What Is The Link Between Obesity And Dvt
Since 1980, obesity has more than doubled around the world. Researchers have found that the number of deep-vein clots is also rising, indicating that obesity may be to blame. While doctors are still looking for an exact reason, they have confirmed that if you have a BMI of 30 or higher, you are more likely to develop a deep vein clot than those who are at a normal weight. When a clot forms deep within the veins, medical professionals refer to the condition as deep vein thrombosis or DVT.
What causes DVT in those who are obese?
If you are overweight, you may have a lifestyle that is less active. When youre idle, your blood flow slows. Also, an excess amount of abdominal fat can prevent blood from moving easily within your bodys deep veins. Both of these issues increase your DVT risk.
Researchers have also found that obesity modifies your blood chemical makeup, causing inflammation to develop. This also increases your chances of getting DVT.
How can I reduce my risk of DVT?
To decrease your risk of DVT, consider losing weight. Not only will it make your legs look and feel better, but weight loss also changes your blood chemistry, lowering your risk of developing many life-threatening diseases.
According to studies, when overweight and obese adults performed a moderately intense aerobic exercise, they saw an improvement in their blood health. This happened for people even if they were unable to lose weight with exercise alone.
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Etiology Of Chronic Venous Insufficiency
Venous return from the lower extremities relies on contraction of calf muscles to push blood from intramuscular sinusoids and gastrocnemius veins into and through deep veins. Venous valves direct blood proximally to the heart. Chronic venous insufficiency occurs when venous obstruction Deep venous thrombosis is clotting of blood in a deep vein of an extremity or the pelvis. DVT is the primary cause of pulmonary embolism. DVT results from conditions… read more ), venous valvular insufficiency, or decreased contraction of muscles surrounding the veins decrease forward venous flow and increase venous pressure . Fluid accumulation in the lower extremities can also contribute by causing venous hypertension. Prolonged venous hypertension causes tissue edema, inflammation, and hypoxia, leading to symptoms. Pressure may be transmitted to superficial veins if valves in perforator veins, which connect deep and superficial veins, are ineffective.
The most common risk factor for chronic venous insufficiency is
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Deep venous thrombosis
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Sitting or standing for long periods
Idiopathic cases are often attributed to a history of occult DVT.
Venous Insufficiency And Varicosities
Chronic venous insufficiency is a common clinical problem whose presentation ranges from mildly unsightly venous dilation to recurrent cellulitis and ulceration requiring frequent hospitalizations. An estimated 20% of the US adult population has some degree of varicose veins, and up to 5% have advanced chronic venous insufficiency and venous ulceration.
The venous system of the lower extremities is composed of deep veins that lie within the muscle fasciawithin or between the muscles, with the latter more implicated in chronic venous insufficiencyand superficial veins that lie outside the deep fascia and muscles. Although the underlying etiology is not fully understood , these disorders result from chronic venous hypertension, which can be caused by incompetence of the venous valves, venous thrombosis or obstruction, and/or failure of the muscular venous pump .
Telangiectasias and reticular veins are dilated intradermal and subdermal veins, respectively. They are present in about 50-66% of individuals, with women being more commonly affected than men.,
Varicose veins are dilated, tortuous, subcutaneous veins usually greater than 3 mm in diameter. They are present in 10-30% of the general population and are particularly frequent in older individuals and women., Most are asymptomatic. However, clinical symptoms may include swelling, aching, tension, leg fatigue, burning, and pruritus, which may be relieved with recumbency or leg elevation.
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Diet For Venous Insufficiency
Aside from all the treatment mentioned, how do we protect our vein health? One important way is to modify our diet. Our diet is a very important factor, not just in the health of our veins, but also for our overall well-being. The food we choose to nourish our body would significantly affect the risk of contracting diseases.
Here are some tips that have been proven to aid venous insufficiency:
How Does Obesity Cause And Worsen Venous Disease
Venous disease, specifically spider veins and varicose veins, is not solely caused by obesity. Oftentimes, if you develop varicose veins or spider veins, its because of a family history of these conditions. However, other risk factors, including obesity, can increase your chances of developing a venous disease or worsening symptoms.
How does obesity affect venous disease?
Spider veins and varicose veins are primarily circulation problems. Changes in the structure of the vein wall, increased venous pressure, and malfunctioning check valves all contribute to venous disease. The increased venous pressure caused by excessive weight increases the rate at which vein wall and valve deterioration develop this causes the blood to pool in the veins. This results with visible, bulging veins that ache and can lead to other complications.
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Obesity And Varicose Veins
Obesity is also linked to problems with varicose veins. If you are overweight and develop varicose veins, the symptoms of the leg condition are often falsely attributed to your weight, delaying the diagnosis until they become visible during the weight loss process. The delay in diagnosis and treatment can result in damage to the skin on the lower left. Left untreated, the risk of leg ulceration increases. Read more about Obesity and Varicose Veins
Causes Of Venous Insufficiency
Venous insufficiency is most often caused by either blood clots or varicose veins.
In healthy veins, there is a continuous flow of blood from the limbs back toward the heart. Valves within the veins of the legs help prevent the backflow of blood.
The most common causes of venous insufficiency are previous cases of blood clots and varicose veins.
When forward flow through the veins is obstructed such as in the case of a blood clot blood builds up below the clot, which can lead to venous insufficiency.
In varicose veins, the valves are often missing or impaired, and blood leaks back through the damaged valves.
In some cases, weakness in the leg muscles that squeeze blood forward can also contribute to venous insufficiency.
Venous insufficiency is more common in women than in men. Its also more likely to occur in adults over the age of 50, according to the Cleveland Clinic.
Other risk factors include:
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Symptoms Of Vein Disease
Vein disease, or venous insufficiency, is indicated by the following symptoms:
- Swelling of the body, mainly legs or ankles.
- Itching and cramping in the legs.
- Throbbing, dull aching, and heaviness in the legs.
- Discoloration of the skin darker and brownish patches on the skin.
- Hard and thick skin of the legs and ankles.
- Sores that are usually open and painful.
- Blood clots are formed.
Risk Factors For Chronic Venous Insufficiency
The following situations or conditions put you at greater risk of venous insufficiency:
- Aging past 40 years
- Having a family history of vein disease
- Personal medical history of blood clots in the legs
- Having a job that requires you to be sitting or standing for long periods of time
Most patients simply think the symptoms of venous insufficiency are caused by aging instead of a serious medical condition. As such, if you notice any of the symptoms of chronic venous insufficiency, you should immediately go to a Vein Treatment Clinic.
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Effect Of Treatments On Renal Function Tests Of Hfd In Rat
The obese rats showed a highly significant increase in the concentration of serum urea, uric acid creatinine, compared with the normal group which is in agreement with the results of Cindik et al. .
Abnormal renal function is mainly associated with diabetic nephropathy. The pathophysiology involves glucose that binds irreversibly to proteins in the kidney circulation to form advanced glycosylation end products that can form complexes that contribute to renal damage by stimulation of fibrotic growth factors .
HFD induces alteration of renal lipid metabolism by an imbalance between lipogenesis and lipolysis in the kidney, as well as systemic metabolic abnormalities and subsequent renal lipid accumulation leading to renal injury . There is an association between CKD and insulin resistance that contributes to increased VLDL production and decreased HDL levels, both of which are considered risk factors for the development of kidney dysfunction and markers for progression of CKD .
In addition HFD resulted in hyperinsulinemia, activation of the renin-angiotensin system, glomerular hyperfiltration and structural changes in the kidney that may be the precursors of more severe glomerular injury associated with prolonged obesity .
Treatments Of Vein Disease
Every person may have a different type of vein disease therefore, he/she will need a different treatment. It is better to consult a professional who can clearly determine which treatment course is suitable for you. The factors that are considered before the treatment of venous insufficiency are mentioned below:
Some treatments of vein disease are:
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Effect Of Diet Treatments On Cardiac Biomarkers In Rats
The obese rats showed a significant increase in the activity of serum LDH, CK-NAC and CK-MB when compared to the normal rats . Similar results were reported by Diniz et al. . Reduced muscle mitochondrial content function with increasing obesity would lower the total cellular ATP yield, which would result most notably in increased mitochondrial volume, and increased glycolytic enzymes necessitating increased activity of creatine kinase, as this enzyme is responsible for rapidly transferring high-energy phosphate groups from the site of production to the site of use .
The increased blood levels of total cholesterol, LDL, VLDL as well as lowered levels of HDL in HFD rat have been identified in the development of hypercholestremia, which is one of the risk factors for CAD . Administration of L-carnitine produces a significant decrease in the activity of CK-NAC, CK-MB and LDH . This is in agreement with Ferrari et al. , who reported a reduction in cardiac markers, with L-carnitine having a good protective effect on myocardium.
This effect is mainly attributable to the vasodilatation property of L-carnitine, which both improves energetic metabolism of the hypoxic/damaged muscle and enhances wash-out of algogenic metabolites.
