Will I Regain Some Weight After I Stop Taking Weight Management Medication
You probably will regain some weight after you stop taking weight management medication. Developing and maintaining healthy eating habits and increasing physical activity may help you regain less weight or keep it off.
Federal physical activity guidelines recommend at least 150 minutes a week of moderate-intensity aerobic activity and at least 2 days a week of muscle-strengthening activities. You may need to do more than 300 minutes of moderate-intensity activity a week to reach or maintain your weight-loss goal.
Naltrexone Hcl And Bupropion
How it works: Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formula. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is approved to treat depression, seasonal affective disorder, and help people stop smoking.
Approved for long-term use? Yes.
Side effects: The most common side effects include nausea, constipation, headache, vomiting, dizziness, insomnia, and dry mouth. Contrave has a boxed warning about the increased risk of suicidal thoughts and behaviors associated with bupropion. The warning also notes that serious neuropsychiatric issues linked to bupropion have been reported. Contrave can cause seizures and must not be used in patients who have seizure disorders. The drug can also increase blood pressure and heart rate.
What else you should know: If you don’t lose 5% of your weight after 12 weeks of taking Contrave, your doctor may tell you to stop taking it, because it’s unlikely to work for you, the FDA says.
The Obesity Crisis: A National Epidemic
According to the U.S. Centers for Disease Control and Prevention , there has been a dramatic increase in obesity in the last 20 years. Based on the most recent numbers, the prevalence of obesity is over 40% and affects roughly 93 million U.S. adults. The prevalence of severe obesity is 9.2% of the population.
These numbers are especially astounding because obesity and obesity-related conditions account for some of the leading causes of preventable deaths in the U.S.
Obesity-related conditions include:
- type 2 diabetes
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In addition, being overweight or obese is a recognized risk factor for many other major health problems including osteoarthritis, sleep apnea and other breathing problems, mental health issues like depression, and gallbladder disease.
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What Are Dietary Supplements
Dietary supplements are intended to add to or supplement the diet and are different from conventional food. Generally, to the extent a product is intended to treat, diagnose, cure, or prevent diseases, it is a drug, even if it is labeled as a dietary supplement. Supplements are ingested and come in many forms, including tablets, capsules, soft gels, gel caps, powders, bars, gummies, and liquids.
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Dietary supplements can help you improve or maintain your overall health, and supplements can also help you meet your daily requirements of essential nutrients.
For example, calcium and vitamin D can help build strong bones, and fiber can help to maintain bowel regularity. While the benefits of some supplements are well established, other supplements need more study. Also, keep in mind that supplements should not take the place of the variety of foods that are important for a healthy diet.
What Are Clinical Trials For Prescription Medications To Treat Overweight And Obesity
Clinical trialsand other types of clinical studiesare part of medical research and involve people like you. When you volunteer to take part in a clinical study, you help health care professionals and researchers learn more about disease and improve health care for people in the future.
Researchers are studying many aspects of prescription medications to treat overweight or obesity, such as
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- adolescents and young adults who dont achieve expected weight loss or who still have severe obesity after undergoing weight-loss surgery
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The favorable FDA ruling is based on results from four phase III clinical trials that tested the drug’s safety and efficacy in more than 4,500 adults with overweight or obesity. The trial participants received either a reduced calorie meal plan and increased physical activity or the lifestyle intervention plus semaglutide.
The results were published in the New England Journal of Medicine, The Lancet , and JAMA in February and March 2021.
In the three of the four trials of individuals with overweight and obesity, those in the semaglutide groups saw 15% to 18% weight loss over 68 weeks.
The dosage was well-tolerated. The most common side effects were gastrointestinal, and they were brief and mild or moderate in severity.
A coauthor of the first trial, Rachel Batterham, PhD, of the Centre for Obesity Research at University College London, said at the time of publication: “The findings of this study represent a major breakthrough for improving the health of people with obesity.”
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Side effects for semaglutide were monitored in the trials leading up to its FDA approval. The most common side effects with semaglutide are gastrointestinaland include nauseaand that is often managed by adjusting the dosage, says Dr. Viana. You consider how the patient feels as the dosage increases, and you can always go back to a lower one, he says.
Dr. Jastreboffs participant in the tirzepatide clinical trial had side effects that included stomach problems, some exhaustion, and difficulty staying hydrated, but the participant thought they were minor compared to the side effects and complications of obesity.
“When I was obese, my joints were aching, I couldnt fit into my clothingI was embarrassed to go out and be seen, she says. We all know airplane seats are getting smaller, but that logic does nothing when youre trying to wedge yourself in between the arms and have to extend the seatbelt to its fullest.
Scientists continue to study the long-term benefits and safety of anti-obesity medications, and will do the same with drugs that are still in the clinical trial phase.
Meanwhile doctors say patients will need to take the medications for yearsand probably for lifeto avoid having the weight come back. We talk about diabetes remission, and, in the same way, patients have obesity remission, Dr. Jastreboff says.
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There are also positive health benefits to losing weight. Losing just five10 percent of your body weight will lower your:
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- For every two pounds you gain, this puts another four pounds of pressure your knees. Being overweight increases your chances of having knee pain.
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Losing weight can improve self-perception and mood, but Dr. Jastreboff emphasizes that the goal of treating obesity is not about achieving a certain sizeits about health.
The goal of treatment with anti-obesity medications is to reset the set point, a term that describes a weight range the body tries to maintain, and one which is elevated in the setting of obesity, she explains. If you lose weight by restricting calories, your body thinks it’s starving, Dr. Jastreboff says, adding that this spurs a person to keep eating to maintain the elevated set point. Anti-obesity medications work in the brain to help to bring that set point down, enabling individuals not only to lose weight but also to maintain the weight loss.
Depending on the patient and their other diseases, anti-obesity medications can also help with other weight-related medical problems, such as improving blood pressure or cholesterol levels, improving blood sugar levels in patient with diabetes, and delaying the onset of type 2 diabetes. The class of GLP-1 analogue medications has also been found to decrease the occurrence of repeat heart attacks and strokes in those who have type 2 diabetes.
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